2008;63(4):427432. doi:10.1161/ATVBAHA.112.300133, 30. da Luz PL, Favarato D, Faria-neto JR Jr, Lemos P, Chagas AC. Complexity of Stomach-brain interaction induced by molecular hydrogen in Parkinsons disease model mice. Fasting blood sugar, lipid profiles, and C-reactive protein (CRP) were determined by Pictus 500 Diatron kits (Medicon Hellas S.A., Gerakas, Greece). At the end of the trial, those who consumed the hydrogen water experienced decreased levels of hydroperoxide a marker of oxidative stress and maintained greater antioxidant activity after radiation treatment than the control group (4). 35. Water molecules consist of two hydrogen atoms and one oxygen atom, but some assert that infusing water with additional hydrogen produces benefits that plain water cannot deliver. Nutr Res. Korovljev D, Stajer V, Ostojic J, LeBaron TW, Ostojic SM. Hydrogen water machines can also be purchased by those wanting to make it at home. A new approach for the prevention and treatment of cardiovascular disorders. If you agree to our use of cookies and the contents of our Privacy Policy please click 'accept'. Fasting blood glucose was measured after an overnight fast. The opinions expressed in all articles published here are those of the specific author(s), and do not necessarily reflect the views of Dove Medical Press Ltd or any of its employees. Obesity (Silver Spring). Plain water is the healthiest choice to keep your body hydrated. Fasting blood glucose also decreased after 24-week HRW intervention from 121.5 61.0 mg/dL to 103.1 33.0 mg/dL, with an accompanying 12% reduction in HbA1C (P < 0.05). this site will not function whilst javascript is disabled. Lastly, although not tested in our study, the previous study32 reported that in 4 of 6 subjects with impaired glucose tolerance, HRW normalized the oral glucose tolerance test, and that 1hr plasma insulin levels were significantly increased compared to baseline.32. Biochem Biophys Res Commun. Copyright 2017 Informa PLC. 2017;42(9):26582665. 2008;28:137143.
Yoshii Y, Inoue T, Uemura Y, et al. Recommend this site Therefore, long-term treatment with high-concentration hydrogen-rich water may be used as an adjuvant therapy to decrease the features of metabolic syndrome. 2019;98:2934. 26. LeBaron TW, Larson AJ, Ohta S, et al. All your questions answered, from how its used to possible health benefits, its side effects, Gluten-free meal prep can take lots of time and planning, which is why meal delivery services can come in handy. This study was partially supported by Slovak Research and Development Agency (APVV)-0241-11, APVV-15-0376; ITMS 26230120009; Scientific grant agency of the Ministry of Education of the Slovak Republic (VEGA) 2/0063/18, and by HRW Natural Health Products Inc. TWL reports personal fees from medical/academic conferencesincluding travel reimbursement, honoraria, and speaking and consultancy fees from various academic and commercial entities regarding molecular hydrogen. PLoS One. Neurochem Res. The participants consumed 1 tablet 3 x daily in 250 mL of 12-18C water. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. Future research should investigate if there are sexually dimorphic responses to H2 therapy, the molecular mechanisms of H2 at physiologically relevant H2 concentrations, and also the comparison of the effects of different doses, durations, and methods of administration (eg drinking vs inhaling). PLoS One.
Molecular hydrogen: an inert gas turns clinically effective. Sixty subjects of Indian ethnicity (30 men and 30 women; age 43.2 10.0 years) with metabolic syndrome were recruited to participate in this double-blinded, placebo-controlled interventional trial. Testimonials Arterioscler Thromb Vac Biol. Nat Med. The number of participants recruited was in accordance with a minimal sample size (n = 48) calculated by power analysis (G*Power 3.1, Heinrich Heine University, Dsseldorf, Germany), with effects size set at 0.30, alpha error probability 0.05, power 0.80 for two groups and two measurements of study outcomes. Written informed consent was obtained from all participants, and the trial was conducted in accordance with the Declaration of Helsinki, and this statement was added to the methods. One 10-week study instructed 20 people with signs of metabolic syndrome to drink 3034 ounces (0.91 liter) of hydrogen-enriched water per day.
Randomized, double-blinded, placebo-controlled crossover pilot study. All authors made substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data; took part in drafting the article or revising it critically for important intellectual content; gave final approval of the version to be published; and agree to be accountable for all aspects of the work. Gvozdjakova A, Kucharska J, Kura B, et al. 5. Oxid Med Cell Longev. doi:10.1371/annotation/ea26285b-dda3-470d-a8df-241df9fbc5ad. You can learn about what data of yours we retain, how it is processed, who it is shared with and your right to have your data deleted by reading our Privacy Policy. Theres a lot of buzz surrounding this beverage but until more research is conducted, its best to take the purported health benefits with a grain of salt. An initial observation period of one week was used to acquire baseline clinical metrics and biochemical data (Table 1), with no differences found between the HRW and the placebo group. This article reviews, Some people believe that drinking a gallon of water per day can significantly benefit their health. Nature. 4. Its pathophysiology is associated with redox dysregulation, excessive inflammation, and perturbation of cellular homeostasis. The favorable changes in blood cholesterol need to be cautiously interpreted since the absolute change was relatively low, and HDL decreased by ~ 1.3 mg/dL. Despite hydrogens ability to ostensibly induce hormesis, and therefore potentially elicit adverse effects, there are no studies either in cells, animals, or humans, even at very high doses, where clear adverse effects have been reported.10 We therefore evaluated the effects of 24-week intervention with high-concentration HRW on body composition, blood lipid profiles and inflammation biomarkers in men and women with metabolic syndrome. doi:10.5551/jat.RV17014, 29. 2019;97(9):797807. 2016;7:392. doi:10.3389/fphar.2016.00392, 20. Can J Physiol Pharmacol. Molecules.
Effects of molecular hydrogen assessed by an animal model and a randomized clinical study on mild cognitive impairment. Molecular hydrogen (H2): potential in mitigating oxidative stress-induced cardiotoxicity. High-concentration HRW was prepared via hydrogen-producing tablets (HRW Natural Health Products Inc., New Westminster BC, Canada) while the placebo was prepared as described previously16,25 with the final placebo drink similar in taste, dissolution, and appearance to HRW. Again, it may be due to our study condition with a higher dose of H2 and the longer time duration. Hydrogen water is generally recognized as safe (GRAS) by the FDA, meaning that its approved for human consumption and not known to cause harm. Hydrogen water is pure water infused with extra hydrogen molecules. Matsumoto A, Yamafuji M, Tachibana T, Nakabeppu Y, Noda M, Nakaya H. Oral hydrogen water induces neuroprotective ghrelin secretion in mice. Moreover, data on food, tobacco, and alcohol intake and physical activity were obtained by dietary diaries and assessed by a dietitian. Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study (1). Compared to previous studies, it may also indicate that high doses of H2 are more effective than lower doses at least in metabolic syndrome. HDL cholesterol is considered to be beneficial due to its role in reverse cholesterol transport.29 However, the ratios of total cholesterol or triglycerides to HDL are better predictors of cardiovascular disease than total cholesterol, with lower ratios correlating with a lower risk for heart disease.30 Since we found that HRW significantly lowered total cholesterol (by ~ 18.5 mg/dL), the ratio of total cholesterol to HDL favorably decreased by ~ 7.2%, whereas it stayed the same in the placebo group. However, you should be aware that theres currently no industry-wide standard on the amount of hydrogen that can be added to water. Hydrogen gas inhalation treatment in acute cerebral infarction: a randomized controlled clinical study on safety and neuroprotection. Its pathophysiology is associated with redox dysregulation, excessive inflammation, and perturbation of cellular homeostasis.2 There is no approved drug to prevent or treat metabolic syndrome. Kamimura N, Ichimiya H, Iuchi K, Ohta S. Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1 [alpha] to enhance fatty acid metabolism. Subjects were then randomized in a double-blind fashion to either intervention (HRW) or placebo group by computer-generated random numbers. For example, as illustrated in the recent review,5 H2 attenuates radiation-induced heart disease and myocardial ischemia-reperfusion injury in rats by decreasing inflammation, apoptosis, sarcoplasmic and oxidative stress, and by regulating microRNAs and autophagy.5 In APOE knockout mice, ingestion of HRW prevented the development of atherosclerosis,18 and H2 also protected against drug-induced cardiac hypertrophy and dysfunction.19. We offer real benefits to our authors, including fast-track processing of papers. Subjects participated in this study if they met at least three of the five inclusion criteria including prehypertension/hypertension (systolic blood pressure [BP] > 130 mmHg and/or diastolic BP > 85 mmHg), prediabetes/diabetes (fasting glucose > 110 mg/dL), central obesity (waist circumference [WC] > 90 cm for men, and WC > 80 cm for women), and dyslipidemia (high-density lipoprotein [HDL] < 40 mg/dL for men and < 50 mg/dL for women; triglycerides [TG] > 200 mg/dL). Hydrogen water can be pricey with one popular company selling a 30-pack of 8-ounce (240-ml) cans for $90 and suggesting consumers drink at least three cans per day. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. software development by maffey.com doi:10.1038/oby.2011.6. 2019;97(9):857862. A study in ten male soccer players found that athletes who drank 51 ounces (1,500 ml) of hydrogen-enriched water experienced lower levels of blood lactate and decreased muscle fatigue after exercise compared to a placebo group (9). 19 Water-Rich Foods That Help You Stay Hydrated, The 8 Best Gluten-Free Meal Delivery Services of 2022. Ir J Med Sci. 2006;444(7121):860867. 8. Obes Rev. The underlying molecular mechanisms that mediate these effects induced by HRW need further study. doi:10.1038/nm1577, 12. Subject baseline data were analyzed using a two-tailed two-sample t-test. 2018;8:362364. AGEs further promote inflammation, oxidation, and cellular damage contributing to cardiovascular disease.28 Accordingly, in our study we determined if high concentration HRW would improve the various biomarkers of metabolic syndrome that are casually involved in the development of cardiovascular disease namely dyslipidemia (HDL, LDL, VLDL, TG), inflammation (TNF-, IL-6, CRP), oxidative stress, (MDA, TBARS, diene conjugates, vitamins E and C,) and hyperglycemia (glucose, HbA1c). Tune JD, Goodwill AG, Sassoon DJ, Mather KJ. Nishimaki K, Asada T, Ohsawa I, et al. Katakami N. Mechanism of development of atherosclerosis and cardiovascular disease in diabetes mellitus. Inflammation and metabolic disorders. HRW induced a significant reduction in total cholesterol by approximately 18.5 mg/dL (P < 0.05), and in triglycerides levels by ~ 47 mg/dL (P < 0.05). More studies are needed to confirm if drinking hydrogen decreases the effects of oxidative stress in both healthy people and those with chronic conditions. Maintaining intestinal H2 balance: credit the colonic bacteria. 2007;13(6):688694. 2013;8(1). However, even this higher H2 concentration was not high enough to result in detectable increases in brain H2 concentration.22 It was subsequently determined that H2-induced secretion of neuroprotective gastric ghrelin, which, as a 2nd messenger, mediated the neuroprotective effects of HRW.22 However, the mechanism appears more complicated since the protective effects of HRW were still observed in a ghrelin-KO mice model of Parkinsons disease.23 Nevertheless, it appears that a higher concentration of H2 is at least as effective as, and often more effective than, a lower H2 concentration. 36. Zhang Y, Xu J, Long Z, et al. 2018;24(45):50955108. However, more dose-dependent studies in this area are needed. Ostojic SM. doi:10.1900/RDS.2006.3.118. Other markers of oxidation (MDA, D-conjugate) decreased while vitamins E and C increased in the HRW group. The hip girth was measured at the greatest circumference at the level of greater trochanters. Two-way mixed model ANOVA with repeated measures (treatment vs time interaction) adjusted for age and gender was used to establish if any significant differences existed between patients responses over time of intervention. However, in our study, the primary change was a decrease in total cholesterol, whereas in the open-label study, it was an increase in HDL cholesterol. This was accompanied by a significant reduction in HR, BMI and WHR after HRW intervention (P < 0.05). Molecular hydrogen fights free radicals in your body and protects your cells from the effects of oxidative stress (3). These favorable changes in cholesterol and glucose are corroborated with a few discrepancies in several previous clinical trials.
Back to Journals Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Volume 13, The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial, Authors LeBaron TW, Singh RB, Fatima G, Kartikey K, Sharma JP, Ostojic SM, Gvozdjakova A, Kura B, Noda M, Mojto V, Niaz MA, Slezak J, Published 24 March 2020 Body weight was measured in underclothes after removing shoes. Cardiovascular consequences of metabolic syndrome. Amitani H, Asakawa A, Cheng KC, et al. World J Gastroenterol. Here are 8 of the top gluten-free. open access to scientific and medical research. Nakao A, Toyoda Y, Sharma P, Evans M, Guthrie N. Effectiveness of hydrogen rich water on antioxidant status of subjects with potential metabolic syndrome-an open label pilot study. For example, Song et al reported that HRW, supplying 0.5 millimoles H2/day, for 10 weeks in patients with potential metabolic syndrome decreased total serum cholesterol and LDL-C levels, improved HDL function and redox status (eg increased serum superoxide dismutase [SOD] and decreased MDA), and reduced inflammation (eg serum TNF-).31 However, whereas our study showed significant improvements in BMI, WHR, and fasting glucose, their study only reported a potential, albeit non-significant, downward trend in these parameters. There may be differences in the biological effects of H2 if HRW is ingested with or without food intake since following ingestion of normal fibers from the diet, bacterial production of H2 gas significantly increases.39 Lastly, we did not measure the temporal changes or pharmacokinetics of H2 in the blood and breath of the subjects. The concentration of molecular hydrogen produced via these tablets was determined by H2 Analytics (Las Vegas, USA) via gas chromatography (SRI 8610C; California USA). LeBaron TW, Laher I, Kura B, Slezak J. Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes (1). Top, Copyright 2022 Dove Press Ltd Theranostics. Values are Mean SD. Mikami T, Tano K, Lee H, et al. This article reviews hydrogen water and its purported health effects to help you decide whether its a smart choice. The product may benefit athletes by reducing inflammation and slowing the accumulation of lactate in the blood, which is a sign of muscle fatigue (8). J Atheroscler Thromb. LeBaron TW, Kura B, Kalocayova B, Tribulova N, Slezak J. All subjects were asked to maintain the same lifestyle throughout the study. doi:10.3748/wjg.v24.i45.5095, 25. An initial observation period of one week was used to acquire baseline clinical data followed by randomization to either placebo or high-concentration HRW (> 5.5 millimoles of H2 per day) for 24 weeks.Results: Supplementation with high-concentration HRW significantly reduced blood cholesterol and glucose levels, attenuated serum hemoglobin A1c, and improved biomarkers of inflammation and redox homeostasis as compared to placebo (P < 0.05).